A 51-year-old cisgender man with chronic HIV and a long history of heroin use has been stable on a methadone dose of 80 mg daily. He has taken efavirenz-tenofovir DF-emtricitabine for 9 years with suppressed HIV RNA levels, but he recently developed depression. He abruptly stopped his antiretroviral medications and said he will restart in several months.
What impact will stopping efavirenz-tenofovir DF-emtricitabine on methadone levels during the next several weeks?
Methadone levels are unlikely to change
Methadone levels are likely to decrease for 6 weeks, then gradually increase
Methadone levels are likely to increase
Methadone levels are likely to decrease
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